ONS ONCC Chemotherapy Renewal Practice Exam

These questions are part of the practice quiz. Start practicing

• What hepatic function markers are evaluated to decide dose reductions in hepatic impairment?
• For extravasation of plant alkaloids such as vinblastine and vincristine, which agent is used as an antidote?
• LVEF monitoring in regimens including Perjeta and trastuzumab should include assessment at baseline and at what interval during neoadjuvant therapy?
• Which statement about growth factor support in high-risk regimens is true?
• What is a common central venous line care practice to maintain patency?
• Which of the following is recommended prophylaxis for at‑risk patients?
• During a paclitaxel infusion, the patient develops throat clearing and shortness of breath. What is the first immediate action?
• Which statement best summarizes the purpose of documenting adverse events during chemotherapy?
• Which symptom cluster is most characteristic of mucositis during chemotherapy?
• What is the recommended management for extravasation of taxanes such as docetaxel and paclitaxel?
• Which two agents are categorized as irritants and prompt consideration of a central access port?
• What is tumor lysis syndrome and what prophylaxis is commonly used?
• Which action should be taken for a suspected high-risk oncology emergency?
• How should central line patency be confirmed before chemotherapy administration?
• What should be included in post-therapy documentation after a chemotherapy session?
• Which scenario best demonstrates appropriate use of two-person verification in chemotherapy administration?
• Which statement about vesicant extravasation signs is true?
• Which statement best describes labeling and disposal of cytotoxic waste?
• Why is AUC preferred over BSA for carboplatin dosing?
• Which of the following is a DNA-binding antineoplastic agent?
• What is the primary purpose of growth factor support in high-risk chemotherapy regimens?
• Which of the following is a potential positive effect of evidence-based practice?
• Which formula is most commonly used in the United States to estimate GFR for dosing carboplatin, and what parameters does it include?
• Trastuzumab and pertuzumab have the potential to cause decline in which organ function?
• In TLS management, rasburicase is preferred in which patients?
• How should a nurse respond to suspected infusion reaction during chemotherapy infusion?
• Which domain is included in a comprehensive geriatric assessment?
• How should a medication order be verified prior to administration of chemotherapy?
• What is an example of a high-risk oncology emergency requiring rapid treatment?
• Which vaccination is recommended for infection prevention in at‑risk patients?
• Which statement best describes vesicants?
• According to NCCN Older Adult Oncology Guidelines (version 1.2015), more than 60% of cancers in the United States occur in people age ____ and older.
• Nadir timing influences laboratory monitoring during chemotherapy by guiding the timing of which test?
• Which of the following is not typically seen with the regimen including docetaxel, carboplatin, trastuzumab, and pertuzumab?
• Which agents require caution in pregnancy due to fetal harm?
• Which chemotherapy agents are most associated with chemotherapy-induced peripheral neuropathy?
• In the administration of the FOLFOX6 regimen, which component is given as a bolus before the infusion?
• Which factor offers the highest risk for developing doxorubicin-related cardiotoxicity?
• Which electrolyte disturbances are commonly seen with tumor lysis syndrome?
• What is the primary safety reason for using a containment device during chemo compounding?
• Which is a sign of venous irritation during vesicant extravasation?
• The risk of developing colorectal cancer increases markedly after age which value?
• Is it always required to use a central venous port for irritant chemotherapy?
• Why is hydration important in TLS prophylaxis?
• Why are antiemetics given as premedication before chemotherapy?
• Which scenario requires PPE due to potential release of hazardous drugs into the environment?
• In tumor lysis syndrome, which electrolyte abnormality is commonly observed?
• At a cumulative doxorubicin dose of 500 mg/m2, what is the approximate risk of cardiotoxicity?
• Which medication is listed as an effective treatment for peripheral neuropathy?
• What are common signs of chemotherapy-induced mucositis?
• What essential education points should be provided to patients using oral chemotherapy at home?
• Which practice is not long recommended for infection prevention?
• What is a critical safety consideration when administering intrathecal chemotherapy?
• Which management step is commonly used for moderate to severe immune-related adverse events from checkpoint inhibitors?
• Which drugs are used as urate-lowering therapy in TLS prophylaxis?
• Which imaging modality is appropriate to assess left ventricular function prior to doxorubicin?
• Which items are verified in two-person verification before chemotherapy administration?
• Which agent in R-CHOP is most likely to cause constipation?
• If neoadjuvant chemotherapy is effective, what surgical option might be possible instead of mastectomy?
• What is the most important late effect monitoring issue related to doxorubicin?
• What is the primary clinical benefit of neoadjuvant chemotherapy in breast cancer?
• Which statement best explains why intrathecal and IV medications should be prepared separately and clearly labeled?
• Which infection prevention measure is unlikely to be effective?
• Which extravasation management is recommended for irinotecan?
• Which interventions are recommended to prevent oral candidiasis in patients with mucositis?
• Per NCCN guidelines, an older patient with a prior neutropenic episode would be a candidate to receive what to reduce neutropenia risk?
• If a central line shows signs of occlusion during flushing, which information should be documented as part of the line assessment?
• What is the recommended dosing method for Hyaluronidase in plant alkaloid extravasation?
• In Totect dosing for anthracycline extravasation, the dose is based on which parameter?
• Clinical trials evaluating outcomes in cancer patients found improved overall survival when receiving an RDI at least what percentage?
• Which patient statement should prompt an immediate clinical assessment during chemotherapy?
• Which is a unique side effect of oxaliplatin?
• Which item is appropriate to include in post-therapy documentation besides the basic drug information?
• What is the recommended treatment for mechlorethamine extravasation?
• Which class would you not anticipate to be part of premedication for a moderately emetogenic regimen?
• Nadir timing influences monitoring by guiding the timing of the CBC. Which option correctly identifies the test involved?
• Which of the following is not recommended for practice in infection prevention?
• Which component is included in the FOLFOX6 regimen?
• For home chemotherapy management, what is of utmost importance to include in patient education?
• Which drug category has no known antidote for extravasation?
• Regarding the sequencing of therapy, which statement is true about paclitaxel and platinum-containing regimens?
• What is a responsible practice when a patient reports a missed chemotherapy dose?
• What is the safest approach to initiating a new chemotherapy order in a patient with a central line?
• What should be documented after addressing a missed chemotherapy dose?
• Why is a MUGA scan performed prior to cycle 3 in regimens including pertuzumab?
• Which antidotes are used for extravasation of anthracyclines and vinca alkaloids, respectively?
• In tumor lysis syndrome, what is the primary role of rasburicase?
• What action is recommended when LVEF falls to 45–49% with a ≥10% absolute decrease from baseline during pertuzumab/trastuzumab therapy?
• What should be included in education about missed doses for home oral chemotherapy?
• What best practices together reduce catheter-related infections?
• What is a hallmark of immune-related adverse events requiring multidisciplinary management?
• Which dietary factor is listed as a risk factor for colorectal cancer?
• Which inherited familial syndromes are listed as risk factors for colorectal cancer?
• How should a nurse introduce chemotherapy safety to a patient and family?
• Name a monoclonal antibody with infusion reaction risk and a management step.
• What is the appropriate approach to address potential drug interactions between chemotherapy and supportive medications?
• Which statement about monitoring LV function after completing therapy is correct?
• What is a critical step to prevent medication misadministration when preparing intrathecal chemotherapy?
• If blood return is not present at the IV site during suspected extravasation, what may have occurred?
• What is a critical difference between vesicant and non-vesicant drugs?
• Which action best reduces infection risk during line access?
• The Cockcroft-Gault equation for estimating GFR incorporates which patient parameters?
• What is the dosing schedule for Totect (dexrazoxane) in anthracycline extravasation on Days 1 through 3?
• What infection precautions are essential for patients with chemotherapy-induced neutropenia?
• Which agent is more likely to cause a hypersensitivity reaction after multiple prior doses?
• What dosing considerations are used when hepatic impairment is present?
• Name an immune checkpoint inhibitor adverse event that requires prompt evaluation.
• Why was a central venous port chosen for Mrs. Turner’s chemotherapy?
• Rasburicase lowers uric acid by converting it to which metabolite?
• Which of the following drugs are vesicants?
• Which statement about paclitaxel treatment is true?
• Chemotherapy dosing is often calculated in which units?
• To review the carboplatin dose calculation, which laboratory result must be available?
• Which laboratory tests are essential for managing chemotherapy-induced myelosuppression?
• In neoadjuvant trials, the incidence of LVEF decline with trastuzumab and docetaxel plus pertuzumab was what percentage compared to trastuzumab and docetaxel alone?
• What is the relevance of USP <800> to handling hazardous drugs in chemotherapy?
• Which statement correctly identifies an interaction that requires adjustment when combining chemotherapy with another drug?
• Besides capecitabine, which class may be associated with hand-foot syndrome?
• How do you calculate Body Surface Area for dosing in adults?
• Which cytotoxic agent is particularly teratogenic and requires strict contraception and pregnancy testing?
• Which administration detail for paclitaxel is advised to minimize infusion-related toxicity?
• A comprehensive geriatric assessment for older cancer patients typically includes which domain?
• In a patient with catheter-related infection signs, what is an appropriate nursing action?
• Which item is not typically included in post-therapy chemotherapy documentation?
• Which factor is most important when adjusting chemotherapy dosing for elderly patients?
• Which of the following drugs is NOT a DNA-binding agent?
• Which measure is recommended for practice to prevent infections in at-risk patients?
• Evidence shows that older patients can safely obtain the same treatment benefits as younger patients when they receive what type of regimens?
• Which action is a key component of managing chemotherapy-induced mucositis?
• In thrombocytopenia, which practice helps minimize bleeding risk?
• What toxicity is of most concern with the first dose of rituximab?
• For early mucositis, which home care step should the nurse instruct?
• What is the role of growth factors in chemotherapy?
• Which of the following is NOT listed as a risk factor for colorectal cancer?
• During infusion of a monoclonal antibody with infusion-reaction risk, which monitoring is essential?
• Which statement accurately describes DNA-binding antineoplastic agents in the context of extravasation?
• Which agent in R-CHOP is most associated with hemorrhagic cystitis?
• Which statement best describes the primary purpose of hub cleaning during IV therapy?
• What heating method is commonly recommended to reduce local discomfort and facilitate restarting a peripheral IV after extravasation?
• Which combination is commonly used for moderately emetogenic regimens?
• Which of the following is a risk factor for colorectal cancer?
• Which non-drug-related factor is a risk for mucositis, independent of chemotherapy or radiation agents?
• Nadir timing in myelosuppression monitoring refers to which of the following?
• During dose verification, which elements should be compared against the prescription/order?
• Which of the following is recommended for mucositis care in clinical practice?
• When should left ventricular function be assessed in patients receiving doxorubicin?
• Which is the lifetime cumulative dose of doxorubicin that should not be exceeded in a patient receiving cyclophosphamide as part of R-CHOP?
• How should a nurse respond to a suspected infusion-related reaction to a monoclonal antibody?
• What is a common feature of PPE for handling chemotherapy spills?
• Which symptoms may occur if docetaxel extravasates?
• Which PPE item is essential when handling hazardous drugs to minimize exposure?
• Prior to initiating doxorubicin, which cardiac assessment is prioritized?
• During the first administration of a monoclonal antibody, how should infusion reactions be assessed?
• Given a WBC of 2.1 with neutrophils 22% and bands 4%, what is the ANC?
• How should a nurse document a suspected hazardous drug spill?
• What is the correct disposal practice for chemotherapy waste?
• In a combination chemotherapy plan, which approach best ensures patient safety?
• Which lifestyle factor puts Mr. Patterson at the greatest risk for developing mucositis?
• Which practice is specifically used to prevent central line–associated bloodstream infections (CLABSI)?
• Which chemotherapy agent is commonly associated with hand-foot syndrome?
• Which item is not included in the standard hazardous drug spill documentation?
• What is recommended when a patient develops infusion-related symptoms during a monoclonal antibody infusion?
• Which antidote is used for extravasation of anthracycline chemotherapy?
• Which supportive measure reduces risk of infection in thrombocytopenic patients?
• In the FOLFOX6 regimen, what is the duration of the continuous infusion for 5-FU?
• For anthracycline extravasation treated with the antidote, when should infusion be started after extravasation?
• What is the most reliable method to verify the correct chemotherapy dose before administration?
• Which education point is essential for safe handling of oral chemotherapy at home?
• How can nurses support patients at risk for hand-foot syndrome?
• What is the correct approach to infection prevention for neutropenia related to chemotherapy?
• Why is it important to document adverse events during chemotherapy?
• What is the general approach to dosing of chemotherapy in elderly patients?
• Which of the following is a risk factor for colon cancer?
• Which drug listed is a DNA non-binding vesicant?
• Which scenario reduces the lifetime cumulative dose of doxorubicin to 450 mg/m2?
• What is the role of prophylactic antiemetics in high-emetogenic chemotherapy?
• What supportive measures help prevent and treat mucositis in chemotherapy patients?
• Which laboratory values are critical to monitor for methotrexate toxicity?
• During platinum-based chemotherapy, which laboratory measurements are most pertinent to assess nephrotoxicity risk?
• Which treatment regimen is used for colorectal cancer described in the material?